Barnsley Woolley suffered an eighth straight defeat and fell to the bottom of Yorkshire Premier South.
The loss to fellow strugglers Wickersley left the Shaw Laners 14 points off safety with three games to play.
Owen Smith and William Nicholson took three wickets as Wickersley posted 248.
Barnsley collapsed to 61 for seven then number nine Lucas Slatter made 67.
The visitors were bowled out for 169.
Cawthorne fell 111 runs short chasing 252 at Tickhill.
Mustafa Shinwari took four wickets and Matt Carroll three.
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Liam Wiles scored 51 but Cawthorne fell from 114 for one to 141 all out.
