Barnsley will look to end a six-game winless run in all competitions when they host Manchester United under 21s on Tuesday from 7pm in the EFL Trophy.
Although he played a fairly strong 11 in the previous trophy game at Notts County last month, with players from the first team group rather than under 21s, head coach Conor Hourihane is expected to make wholesale changes from the league draw at Bradford with another derby on Saturday at home to Rotherham.
Teenage striker Leo Farrell can play in the EFL Trophy games despite being loaned out to Guiseley but came off injured on Saturday.
The two sides also met last season, with the Reds leading 2-0 thanks to a Vimal Yoganathan brace before conceding three times between the 81st and 87th minute then losing 3-2.
Jacob Devaney, the son of former Barnsley player and coach Martin Devaney, is a regular with the United under 21s and could once again play at his hometown club.
This season, Barnsley started the group stage with a 2-1 loss at Notts County, with a red card for Jono Bland who will be suspended for Tuesday’s fixture.
Lincoln City – who Barnsley host in the final group game on November 11 – are currently top having beaten both County and Manchester United under 21s 3-0.
Barnsley have lost their last six trophy games across three seasons while this will be their first match at home in any competition for almost a month since the 2-0 league defeat against Port Vale on September 27.
Hourihane told the Chronicle: “The plan is to get a win. We will go into the game with the right mindset and attack it as always.
“It will be very different to Bradford but whoever we’re playing we need to have the right mindset and get the right results.”