The driver of an articulated lorry has been arrested on suspicion of dangerous driving following a five vehicle pile-up on the A616 in Tankersley.
The man, 60, of Cudworth, was held by police investigating the smash which left two people with serious injuries.
Officers are appealing for witnesses to the incident that occurred at about 4.40pm on Wednesday between Thorncliffe Road and Tankersley roundabout.
Traffic had been queuing along the A616 when an articulated HGV was in a collision with the rear of a Renault Scenic, which led to subsequent collisions with a Vauxhall Corsa, a Nissan van and another HGV, said police.
The driver of the Nissan van, a man, 18, of Manchester, suffered a broken arm and a serious leg injury. He is being treated at Barnsley Hospital.
The woman driving the Vauxhall Corsa, a 31-year-old from Sheffield, was trapped inside her vehicle for an hour, before being recovered. She is being treated at Northern General Hospital for serious injuries.
A passenger in the Renault Scenic suffered whiplash and was taken to Northern General. Other drivers received minor injuries, which did not require hospital treatment.
Witnesses should contact 101, quoting incident 807 of Wednesday May 30.
